Betty Nguyen has anchored during several breaking news events, including the death of Pope John Paul II in April 2005 and the London bombing attacks in July 2005. She also anchored portions of CNN’s coverage of the tsunami disaster in South Asia, the Iraqi elections in January 2005 and the June 28, 2004, handover of sovereignty to Iraq. Additionally, she contributed to the network's comprehensive coverage of Florida hurricanes Charley, Frances, Ivan and Jeanne.

Before joining CNN, Nguyen was an anchor for KTVT in Dallas. During her six-year tenure with the CBS affiliate, she covered numerous breaking news events including the Space Shuttle Columbia disaster and the Sept. 11 terrorist attacks on the World Trade Center towers in New York. In 2003, she won the Legacy of Women Award, was named a Great Women of Texas Honoree and won a regional Emmy award for "Outstanding Noon Newscast" while at KTVT.

Nguyen began her career as a morning anchor and reporter at KWTX in Waco, Texas. During her tenure with the CBS affiliate, she received an Associated Press Award for spot news coverage.

Nguyen also served as a freelance correspondent for E! Entertainment Television during the 2003 California gubernatorial election.

While conducting several humanitarian aid trips to her birth country of Vietnam, she provided extensive coverage of the deadly flooding along the Mekong Delta.

Nguyen is the co-founder of Help the Hungry, an organization that strives to alleviate global hunger by distributing humanitarian relief to poverty-stricken families. Her philanthropic work earned her a spot in the Philanthropy in Texas Hall of Fame.

Nguyen graduated magna cum laude from the University of Texas at Austin with a bachelor's degree in broadcast journalism. She is a member of the Asian American Journalists Association.